Terns Pharmaceuticals, Inc. Overview
Pro stress-test →Terns Pharmaceuticals is a clinical-stage biopharmaceutical company that develops small-molecule product candidates for the treatment of oncology and obesity. The company completed its transition to an oncology company anchored by TERN-701, an allosteric BCR-ABL inhibitor for chronic myeloid leukemia (CML).
Strategic Profile
Pro stress-test →TERN-701 is a highly selective allosteric BCR-ABL inhibitor with a potentially best-in-disease profile that could meaningfully improve upon the efficacy, safety and convenience of existing CML treatments. The Phase 1 CARDINAL trial showed a 75% cumulative major molecular response (MMR) rate by 24 weeks with 100% MMR durability and encouraging safety across doses.
Competitive Landscape
Pro stress-test →TERN-701 is positioned against second-generation TKI competitors including dasatinib, nilotinib, and bosutinib in planned pivotal trials. The allosteric mechanism and enhanced safety profile offer potential differentiation in the CML treatment space. Multiple phase-appropriate clinical candidates are in development at competing biotech and established pharmaceutical companies.
Industry Context
Terns Pharmaceuticals, Inc. operates in Biopharmaceutical/Clinical-Stage Oncology.
Key facts
Founded: 2015 · Headquarters: Foster City, United States · Market cap: $3.4B