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Phio Pharmaceuticals Corp.: Business Overview, Financials & Competitive Analysis

Phio Pharmaceuticals is a clinical-stage biopharmaceutical company developing immuno-oncology therapeutics based on its proprietary INTASYL self-delivering siRNA technology platform. The company is advancing PH-762, a...

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Phio Pharmaceuticals Corp. OverviewStrategic ProfileCompetitive LandscapeIndustry ContextKey facts
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5/ 10Mixed

Cyborg Score thesis

Promising immuno-oncology platform with positive early clinical signals, but extreme capital constraints and clinical stage...

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Industry Biopharmaceutical/Immuno-Oncology
3 named competitors
3 recent developments
11 analyst dimensions
Synthesized from analyst-debate stress-testing across 11 dimensions and hundreds of data points. Methodology →
Cyborg Score recalibrated: June 15, 2026
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Phio Pharmaceuticals Corp. Overview

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Phio Pharmaceuticals is a clinical-stage biopharmaceutical company developing immuno-oncology therapeutics based on its proprietary INTASYL self-delivering siRNA technology platform. The company is advancing PH-762, a lead candidate in Phase 1b trials for cutaneous squamous cell carcinoma and melanoma, with recent results showing promising safety and efficacy signals.

Strategic Profile

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Co-founded by Nobel Prize scientist Craig Mello (RNAi discoverer), Phio leverages advanced gene silencing technology to enhance immune cell effectiveness against tumor cells without requiring specialized drug delivery systems. The company is transitioning from discovery to development with recent leadership strengthening to support regulatory engagement and clinical advancement.

Competitive Landscape

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Phio competes in the immuno-oncology space against larger companies with established checkpoint inhibitors and cell therapies. Key differentiators include self-delivering siRNA technology avoiding complex formulations, and focus on underexplored targets (PD-1, BRD4) in skin cancers. Competitive positioning is early-stage with limited direct comparables; clinical validation and manufacturing scale-up are critical

Industry Context

Phio Pharmaceuticals Corp. operates in Biopharmaceutical/Immuno-Oncology.

Key facts

Founded: 2011 · Headquarters: Marlborough, Massachusetts, US · Employees: Unknown · Revenue: N/A · Market cap: $11.6M

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The top findings that survived the multi-agent debate for Phio Pharmaceuticals Corp..

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Recent developments

Material events tracked by the AskCyborg corpus.

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Named competitors

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Checkpoint InhibitorsEstablished immuno-oncology class with PD-1/PD-L1 therapiesCell Therapy PlatformsAdvanced cellular immunotherapy approachesEarly-Stage siRNA OncologyAlternative RNAi and gene silencing technologies

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Industry context

Phio Pharmaceuticals Corp. operates in Biopharmaceutical/Immuno-Oncology. See how the rest of the sector scores on the Cyborg framework.

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Frequently asked questions

What does Phio Pharmaceuticals Corp. do?+
Phio Pharmaceuticals is a clinical-stage biopharmaceutical company developing immuno-oncology therapeutics based on its proprietary INTASYL self-delivering siRNA technology platform. The company is advancing PH-762, a...
What is Phio Pharmaceuticals Corp.'s Cyborg Score?+
Phio Pharmaceuticals Corp. has a Cyborg Score of 5/10 (Mixed). The score synthesizes business model, financials, leadership, competitive position, technology, marketing, and ESG dimensions across hundreds of data points.
Who are Phio Pharmaceuticals Corp.'s main competitors?+
Named competitors include Checkpoint Inhibitors, Cell Therapy Platforms, Early-Stage siRNA Oncology. The full competitive landscape is in the AskCyborg report.
How can I get the full Phio Pharmaceuticals Corp. research report?+
Get the report plus analyst-debate audio at askcyborg.com -- no credit card required for preview access. Pro adds saved-company audio playlists and monitoring.
How current is the Phio Pharmaceuticals Corp. research?+
The Cyborg Score is recalibrated weekly. Recent developments are tracked continuously and surfaced in every report.

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