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DURECT Corporation: Business Overview, Financials & Competitive Analysis

DURECT Corporation is a late-stage biopharmaceutical company engaged in the development of epigenetic therapies that target dysregulated DNA methylation to treat serious and life-threatening conditions, including acut...

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DURECT Corporation OverviewStrategic ProfileCompetitive LandscapeIndustry ContextKey facts
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4/ 10Mixed

Cyborg Score thesis

Early-stage epigenetic therapy platform with promising lead candidate but challenged by minimal revenue and dependency on Phase 3...

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Industry Pharmaceuticals
3 named competitors
3 recent developments
11 analyst dimensions
Synthesized from analyst-debate stress-testing across 11 dimensions and hundreds of data points. Methodology →
Cyborg Score recalibrated: October 19, 2026
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DURECT Corporation Overview

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DURECT Corporation is a late-stage biopharmaceutical company engaged in the development of epigenetic therapies that target dysregulated DNA methylation to treat serious and life-threatening conditions, including acute organ injury. Its lead drug candidate, Larsucosterol, is in clinical development for alcoholic hepatitis (AH) with FDA Fast Track and Breakthrough Therapy designations, and is also being explored for metabolic dysfunction-associated steatohepatitis (MASH).

Strategic Profile

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The company has a commercial pharmaceutical product, POSIMIR (bupivacaine solution), a non-opioid analgesic utilizing the SABER platform technology. As of September 2025, DURECT operates as a subsidiary of Bausch Health Americas with $12M in cash reserves and has shifted focus to advancing Larsucosterol with a Phase 3 trial estimated at $20M.

Competitive Landscape

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DURECT's Larsucosterol targets epigenetic dysregulation in alcoholic hepatitis and MASH, competing in the growing liver disease therapeutic space against companies developing anti-fibrotic and metabolic therapies. The company faces competition from larger pharma and biotech firms with more substantial clinical pipelines and financial resources for Phase 3 trials.

Industry Context

DURECT Corporation operates in Pharmaceuticals.

Key facts

Founded: 1998 · Headquarters: Cupertino, California · Revenue: $2M (2024) · Market cap: N/A

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Recent developments

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Industry context

DURECT Corporation operates in Pharmaceuticals. See how the rest of the sector scores on the Cyborg framework.

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Frequently asked questions

What does DURECT Corporation do?+
DURECT Corporation is a late-stage biopharmaceutical company engaged in the development of epigenetic therapies that target dysregulated DNA methylation to treat serious and life-threatening conditions, including acut...
What is DURECT Corporation's Cyborg Score?+
DURECT Corporation has a Cyborg Score of 4/10 (Mixed). The score synthesizes business model, financials, leadership, competitive position, technology, marketing, and ESG dimensions across hundreds of data points.
Who are DURECT Corporation's main competitors?+
Named competitors include Selonsertib, Resmetirom, FibroGenesis Pipeline. The full competitive landscape is in the AskCyborg report.
How can I get the full DURECT Corporation research report?+
Get the report plus analyst-debate audio at askcyborg.com -- no credit card required for preview access. Pro adds saved-company audio playlists and monitoring.
How current is the DURECT Corporation research?+
The Cyborg Score is recalibrated weekly. Recent developments are tracked continuously and surfaced in every report.

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