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MacroGenics, Inc.: Business Overview, Financials & Competitive Analysis

MacroGenics, Inc. scores 3/10 on the AskCyborg Cyborg Score (Challenged). While analysts suggest moderate buy potential with a $3.4 target price, execution risks and regulatory setbacks present high clinical and financial uncertainty. The company faces significant financial distress with an Altman Z-Score of -5.61 indicating potential bankruptcy risk within two years. Recent FDA setbacks include a partial clinical hold on.

What is MacroGenics, Inc.'s industry? MacroGenics, Inc. (macrogenics.com) operates in Biopharmaceutical - Oncology/Immunotherapy. AskCyborg classifies MacroGenics, Inc. under Biopharmaceutical - Oncology/Immunotherapy in its company registry.

MacroGenics is a biotechnology company focused on discovering and developing antibody-based therapeutics for cancer treatment, with its approved product MARGENZA for metastatic HER2-positive breast cancer. The company...

3/ 10Challenged

Cyborg Score thesis

While analysts suggest moderate buy potential with a $3.4 target price, execution risks and regulatory setbacks present high...

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Industry Biopharmaceutical - Oncology/Immunotherapy
3 named competitors
3 recent developments
11 analyst dimensions
Synthesized from analyst-debate stress-testing across 11 dimensions and hundreds of data points. Methodology →
Cyborg Score recalibrated: November 2, 2026
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MacroGenics, Inc. OverviewStrategic ProfileCompetitive LandscapeIndustry ContextKey facts
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MacroGenics, Inc. Overview

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MacroGenics is a biotechnology company focused on discovering and developing antibody-based therapeutics for cancer treatment, with its approved product MARGENZA for metastatic HER2-positive breast cancer. The company maintains collaborations with TerSera Therapeutics, Incyte Corporation, and Gilead Sciences.

Strategic Profile

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The company operates a pipeline of bispecific and antibody-drug conjugate candidates targeting tumor-associated antigens and immune checkpoint molecules, including lorigerlimab, MGC026, and MGC028. MacroGenics leverages proprietary Fc engineering and Dual Activating ReTargeting technology to improve antibody functions and eliminate cancer cells.

Competitive Landscape

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Top competitors include Moderna, Jazz Pharmaceuticals, and BeiGene. MacroGenics operates in a crowded oncology immunotherapy space where multiple companies develop checkpoint inhibitors and antibody-drug conjugates. The company's focus on proprietary Fc engineering and DART technology differentiates it, though recent safety setbacks have weakened its competitive position.

Industry Context

MacroGenics, Inc. operates in Biopharmaceutical - Oncology/Immunotherapy.

Key facts

Founded: 2000 · Headquarters: Rockville, US · Employees: 391 · Revenue: $149.96M (2024) · Market cap: $126M

What the AI analysts debated

AI-generated and not independently verified: selected findings from the multi-agent debate on MacroGenics, Inc..

  • FDA placed partial clinical hold on lorigerlimab Phase 2 trial in February 2026 due to serious safety events including thrombocytopenia, myocarditis, and fatal septic shock in 41 participants
  • Company had $146.4M in cash and marketable securities as of Sept 2025, with expected partnering payments extending runway into late 2027
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Recent developments

Material events tracked by the AskCyborg corpus.

  • February 2026FDA partial clinical hold on Phase 2 LINNET lorigerlimab trial due to safety concerns
  • November 2025Q3 2025 results showed $72.8M revenue; stopped mCRPC development but progressing LINNET study
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Named competitors

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mRNA Vaccines & ImmunotherapiesLeading mRNA therapeutic platform for cancer and infectious diseases→Oncology & Psychiatry TherapeuticsDiversified biopharmaceutical company with oncology focus→Oncology & ImmunotherapyChinese-based global biopharmaceutical company developing cancer therapies→

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Industry context

MacroGenics, Inc. operates in Biopharmaceutical - Oncology/Immunotherapy. See how the rest of the sector scores on the Cyborg framework.

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Frequently asked questions

What does MacroGenics, Inc. do?+
MacroGenics is a biotechnology company focused on discovering and developing antibody-based therapeutics for cancer treatment, with its approved product MARGENZA for metastatic HER2-positive breast cancer. The company...
What is MacroGenics, Inc.'s Cyborg Score?+
MacroGenics, Inc. has a Cyborg Score of 3/10 (Challenged). The score synthesizes business model, financials, leadership, competitive position, technology, marketing, and ESG dimensions across hundreds of data points.
Who are MacroGenics, Inc.'s main competitors?+
Named competitors include mRNA Vaccines & Immunotherapies, Oncology & Psychiatry Therapeutics, Oncology & Immunotherapy. The full competitive landscape is in the AskCyborg report.
How can I get the full MacroGenics, Inc. research report?+
Get the report plus analyst-debate audio at askcyborg.com -- no credit card required for preview access. Pro adds saved-company audio playlists and monitoring.
How current is the MacroGenics, Inc. research?+
The Cyborg Score is recalibrated weekly. Recent developments are tracked continuously and surfaced in every report.

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