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Autolus Therapeutics plc: Business Overview, Financials & Competitive Analysis

Autolus Therapeutics plc scores 6/10 on the AskCyborg Cyborg Score (Solid). Early commercial success with profitability inflection opportunity, but manufacturing scale-up risk and regulatory timing in new indications require vigilant monitoring. The company reported 2025 revenue of $75 million with 2026 guidance of $120-$135 million, representing 80-129% revenue growth accelerating faster than the 60% historical growth rate. However, the company.

What is Autolus Therapeutics plc's industry? Autolus Therapeutics plc (autolus.com) operates in Biopharmaceutical/Cell Therapy - CAR-T and Engineered T Cell Therapeutics. AskCyborg classifies Autolus Therapeutics plc under Biopharmaceutical/Cell Therapy - CAR-T and Engineered T Cell Therapeutics in its company registry.

Autolus Therapeutics is a commercial-stage biopharmaceutical company developing next-generation T cell therapies for cancer and autoimmune disease. Using proprietary modular T cell programming technologies, the compan...

6/ 10Solid

Cyborg Score thesis

Early commercial success with profitability inflection opportunity, but manufacturing scale-up risk and regulatory timing in new...

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Industry Biopharmaceutical/Cell Therapy - CAR-T and Engineered T Cell Therapeutics
3 named competitors
4 recent developments
11 analyst dimensions
Synthesized from analyst-debate stress-testing across 11 dimensions and hundreds of data points. Methodology →
Cyborg Score recalibrated: September 14, 2026
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Autolus Therapeutics plc OverviewStrategic ProfileCompetitive LandscapeIndustry ContextKey facts
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Autolus Therapeutics plc Overview

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Autolus Therapeutics is a commercial-stage biopharmaceutical company developing next-generation T cell therapies for cancer and autoimmune disease. Using proprietary modular T cell programming technologies, the company engineers precisely targeted T cell therapies designed to recognize target cells, overcome their defense mechanisms and eliminate them.

Strategic Profile

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The company achieved a successful US launch of its lead product AUCATZYL with full year 2025 sales well above expectations and more than 60 treatment centers offering the therapy, while establishing reliable, high-quality product delivery with consistent turnaround time. AUCATZYL received regulatory approval from the FDA, EMA and MHRA for adult r/r B-ALL and launched commercially in the US and UK in 2025, positioning Autolus for expansion into autoimmune indications.

Competitive Landscape

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Autolus competes in the CAR-T therapy space with a marketed therapy (AUCATZYL) and a pipeline of candidates for hematological malignancies, solid tumors and autoimmune diseases. Primary competitors include Juno Therapeutics (Beταgenix), Gilead (Yescarta family), and emerging players in next-generation T cell engineering. The company's differentiation centers on proprietary modular programming technology and favorable safety profile.

Industry Context

Autolus Therapeutics plc operates in Biopharmaceutical/Cell Therapy - CAR-T and Engineered T Cell Therapeutics.

Key facts

Founded: 2014 · Headquarters: London, United Kingdom · Revenue: $75M (2025)

What the analysts stress-tested

The top findings that survived the multi-agent debate for Autolus Therapeutics plc.

  • Q4 2025 product revenue reached approximately $24 million, achieving approximately $75 million for full year 2025 in first commercial year.
  • CARLYSLE trial data show encouraging DORIS responses and immune reset in lupus patients; 50M cell dose selected as recommended Phase 2 dose with Phase 2 trial design aligned with FDA for lupus nephritis registrational path.
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Recent developments

Material events tracked by the AskCyborg corpus.

  • February 2026Inducement stock option grants announced under Nasdaq rules for new employee hiring
  • January 2026Announced partnership with Cellares to evaluate automated cell manufacturing platform for scalability
  • +2 moreTrack every material event for Autolus Therapeutics plc as it happens. Explore monitoring →
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Named competitors

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Industry context

Autolus Therapeutics plc operates in Biopharmaceutical/Cell Therapy - CAR-T and Engineered T Cell Therapeutics. See how the rest of the sector scores on the Cyborg framework.

Top companies in Biopharmaceutical by Cyborg Score

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Frequently asked questions

What does Autolus Therapeutics plc do?+
Autolus Therapeutics is a commercial-stage biopharmaceutical company developing next-generation T cell therapies for cancer and autoimmune disease. Using proprietary modular T cell programming technologies, the compan...
What is Autolus Therapeutics plc's Cyborg Score?+
Autolus Therapeutics plc has a Cyborg Score of 6/10 (Solid). The score synthesizes business model, financials, leadership, competitive position, technology, marketing, and ESG dimensions across hundreds of data points.
Who are Autolus Therapeutics plc's main competitors?+
Named competitors include Yescarta/Yescarta 2, Tecartus, Kymriah. The full competitive landscape is in the AskCyborg report.
How can I get the full Autolus Therapeutics plc research report?+
Get the report plus analyst-debate audio at askcyborg.com -- no credit card required for preview access. Pro adds saved-company audio playlists and monitoring.
How current is the Autolus Therapeutics plc research?+
The Cyborg Score is recalibrated weekly. Recent developments are tracked continuously and surfaced in every report.

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