Tyra has outlined its "dabogratinib 3x3" strategy targeting LG-UTUC, IR NMIBC and achondroplasia, with oral dabogratinib as a potential first-in-class selective FGFR3 inhibitor. CEO Todd Harris narrowed the company's focus to "highest value opportunities" for dabogratinib in three lead areas: low-grade upper tract urothelial carcinoma (UTUC), intermediate-risk non-muscle invasive bladder cancer (NMIBC), and skeletal dysplasias with achondroplasia.
Cyborg Score Rationale
9 analysts recommend buying the stock with a Strong Buy rating. The company holds $256.0 million in cash and marketable securities with stated runway through at least 2027. Key near-term catalysts include SURF302 interim data by end 1H 2026 and BEACH301 safety sentinel results in 2H 2026.
Top Insights
Dabogratinib's selectivity is designed to reduce toxicities associated with FGFR1 and FGFR2 inhibition, which have complicated the use of pan-FGFR inhibitors.
Full-year 2025 R&D rose to $102.9M with net loss of $119.9M.
The company expects to report initial three-month complete response data by end 1H 2026.
Average 12-month price target is $43.50 with analyst consensus of Strong Buy (9 buy, 0 sell).
Named Competitors
Erdafitinib/FGFR inhibitors — Approved pan-FGFR inhibitor with broader toxicity profile
CNP-based therapies for achondroplasia — Established competitor in skeletal dysplasia treatment
FGFR3 selective inhibitor programs — Competing FGFR3-selective program with different tolerability profile
Recent Developments
(March 2026) Narrowed dabogratinib focus to "3x3" strategy targeting LG-UTUC, IR NMIBC and achondroplasia
(March 2026) Reported Q4 and FY 2025 results with $256M cash runway through 2027
(February 2026) Multiple analyst upgrades including Wedbush price target raised to $53, Raymond James to $55
(February 2026) ASCO GU 2026 presentation of SURF301 metastatic urothelial cancer response and biomarker data
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