Kaleido Biosciences, Inc. — Cyborg Score 2/10

Challenged
Microbiome therapeutics

Strategic Profile

Kaleido differentiated itself through its novel approach to activating rather than inhibiting microbiome function. Founded by Flagship Pioneering in stealth mode (2015–2017) with an experienced management team and expanded pipeline, the company went public on NASDAQ in 2019 but ultimately ceased operations.

Cyborg Score Rationale

The company is defunct as of 2025. While it raised $165M across three funding rounds and achieved NASDAQ listing, it failed to advance therapies through clinical development successfully or secure continued investor confidence.

Top Insights

  • Developed proprietary Microbiome Metabolic Therapies (MMTs) platform targeting microbial metabolism modulation
  • Backed by Flagship Pioneering with $65M at launch and raised total $165M across 3 rounds (Series A–C completed by June 2018)
  • Achieved NASDAQ IPO in 2019 under ticker KLDO with experienced leadership including former Cubist Pharmaceuticals CEO Mike Bonney
  • Company has ceased operations and is classified as deadpooled as of 2025

Named Competitors

  • Therapeutic Programs — mRNA therapeutics platform
  • Jazz Pharmaceuticals — Specialty pharmaceuticals

Recent Developments

  • (June 2020) CEO Alison Lawton stepped down for family health reasons; Mike Bonney led Office of the CEO transition
  • (September 2019) CFO Joshua Brumm transitioned out; company initiated internal accounting restructuring
  • (2025) Company status listed as inactive/deadpooled

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