Valneva SE — Cyborg Score 6/10

Solid
Specialty Vaccines / Infectious Disease Therapeutics

Strategic Profile

Valneva operates multi-site manufacturing infrastructure across Scotland, Sweden, and Austria, positioning it to serve global markets across North America and Europe. The company is transitioning from travel vaccine focus to address significant unmet medical needs in endemic infectious diseases, with recent positive clinical data supporting advancement of pipeline programs toward market expansion and diversification.

Cyborg Score Rationale

Valneva demonstrates solid fundamentals with approved commercial products generating growing revenues and advancing clinical pipelines. However, regulatory setbacks (FDA suspension of IXCHIQ), operational complexities, and the need for significant capital investment to commercialize pipeline candidates limit upside potential in the near-to-medium term.

Top Insights

  • 2024 revenue was $169.58 million, an increase of 10.32% compared to the previous year's $153.71 million
  • Analyst consensus rates the stock as "Strong Buy" with a 12-month price target of $15.75, implying 56.87% upside
  • Advanced pipeline includes VLA15 for Lyme disease, S4V2 for shigellosis, VLA1601 for Zika, and programs targeting human metapneumovirus, C. difficile infection, and Epstein-Barr virus
  • Recent regulatory headwinds including FDA suspension of IXCHIQ require careful monitoring; company navigating commercialization while managing manufacturing and clinical development complexity

Named Competitors

  • GARDASIL/SILGARD — Infectious disease vaccines
  • TYVERIX — Travel and infectious disease vaccines
  • PENTACEL — Vaccine platform and travel vaccines
  • Lyme Disease Vaccine Programs — Emerging vaccine candidates

Recent Developments

  • (December 2025) Announced positive antibody persistence and safety data for Lyme disease vaccine VLA15 from Phase 2 trial
  • (December 2025) Reported positive Phase 1 results for Zika vaccine VLA1601 with positive immunogenicity data
  • (September 2025) Announced positive antibody persistence data four years post-vaccination from IXCHIQ clinical program
  • (August 2025) FDA suspended license for IXCHIQ following reports of serious adverse events

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