Raphael Pharmaceutical Inc. — Cyborg Score 4/10

Mixed
Cannabinoid-based therapeutics

Strategic Profile

The company is advancing a novel research platform built on highly purified cannabinoids that are free of THC and CBD, with an emphasis on inflammatory and autoimmune diseases. The company develops a lead product candidate for the treatment of rheumatoid arthritis and intends to develop cannabinoid-based drug products for the treatment of oncology indications and other autoimmune diseases.

Cyborg Score Rationale

The company shows significant operating challenges with negative operating income of $1.5M, negative operating cash flow of $532K, and a current ratio of 0.03 indicating short-term liquidity concerns. As a clinical-stage biotech, execution on its cannabinoid-based pipeline is critical to long-term viability.

Top Insights

  • Core focus on non-psychoactive cannabinoids (THC/CBD-free) for inflammatory and autoimmune diseases represents differentiation vs. broader cannabis industry
  • Lead program in rheumatoid arthritis with completed studies; asthma candidates in pre-clinical stage signal pipeline expansion
  • Traded on OTC markets as a micro-cap with material cash constraints limiting clinical development velocity
  • Technology platform emphasizes cannabinoid modulation of immune response and inflammatory pathways—addressing high unmet medical needs in RA, oncology, and autoimmune indications

Named Competitors

  • Rinvoq — JAK inhibitor for rheumatoid arthritis
  • Kevzara — IL-6 antagonist for RA
  • Opdivo — PD-1 inhibitor for oncology indications
  • GWP42006 — Cannabinoid-based therapeutic development

Recent Developments

  • (March 2026) Most recent SEC filing submitted showing financial statements and operational updates
  • (May 2021) Company completed share exchange, merging Israeli Raphael Pharmaceutical Ltd. with US-listed Easy Energy Inc.

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