Odonate Therapeutics, Inc. — Cyborg Score 1/10

Challenged
Oncology therapeutics development

Strategic Profile

Odonate's strategic focus was on creating a patient-friendly oral alternative to intravenously-administered taxanes with improved quality-of-life outcomes. The company conducted the CONTESSA Phase 3 trial for metastatic breast cancer but failed to generate approvable clinical data.

Cyborg Score Rationale

The company ceased operations in March 2021 following FDA rejection of its lead clinical program. No active development pipeline, no operations, and the company exists in a dormant or wound-down state.

Top Insights

  • Lead program tesetaxel failed FDA approval in March 2021 due to insufficient clinical evidence
  • Company was founded in 2013 and went public via IPO, but operations have ceased
  • Oral taxane formulation was designed to improve patient convenience versus IV alternatives
  • No active operations or development pipeline as of current date

Named Competitors

  • Taxol/Paclitaxel — IV taxane chemotherapy (gold standard)
  • Taxotere/Docetaxel — IV taxane chemotherapy

Recent Developments

  • (March 2021) Company ceased operations and closed following FDA rejection of tesetaxel clinical data

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